Hereditary Persistence of Fetal Hemoglobin in Greece
نویسنده
چکیده
By PHAEDON FESSAS AND GEORGE STAMATOYANNOPOULOS H EREDITARY PERSISTENCE of fetal hemoglobin was described in a Greek family in 1961 and included the combination of this anomaly with aand with -thalassemia.1’2 Since then, further cases or families have been observed in Greece, two of which have been reported in whole or in part in Greek medical literature.3’4 This material now permits an adequate appraisal of certain of its aspects; moreover, it warrants a comparison with the hereditary persistence of fetal hemoglobin described in Negroes. The findings in the latter have been recently the subject of an excellent review and discussion by Conley et al.,5 which will serve as the main basis for comparison. Geographical distribution: The affected persons originated from ‘arous parts of Greece: the Aegean islands, Macedonia, Thessaly, the Peloponnese and Epirus. A reasonable estimate of the frequency of the abnormality would be close to 1 heterozygote per 500 persons; thus, one heterozygote was found among 430 individuals from Kard tsa (Thessaly) and another among 550 persons from Arta (Epirus).
منابع مشابه
Persistence of Fetal Hemoglobin in Greece
By PHAEDON FESSAS AND GEORGE STAMATOYANNOPOULOS H EREDITARY PERSISTENCE of fetal hemoglobin was described in a Greek family in 1961 and included the combination of this anomaly with aand with -thalassemia.1’2 Since then, further cases or families have been observed in Greece, two of which have been reported in whole or in part in Greek medical literature.3’4 This material now permits an adequat...
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H EREDITARY PERSISTENCE OF FETAL HEMOGLOBIN is a term tentatively applied to a specific inherited anomaly manifested throughout life by the presence of large amounts of fetal hemoglobin in the erythro-cytes in the absence of anemia or clinical manifestations. The abnormality is attributable to a single autosomal genetic factor. Since the primary effect of the mutant gene is unknown, designation...
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